Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2013Pharmacognosy MagazineOpen Access

Cardioprotective effect of Vedic Guard against doxorubicin-induced cardiotoxicity in rats: A biochemical, electrocardiographic, and histopathological study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Vedic Guard prevent doxorubicin-induced cardiotoxicity in rats?

Population

Rats with doxorubicin-induced cardiotoxicity (15 mg/kg for 2 weeks)

Comparison

Vedic Guard administered as pre-treatment for 2… vs Doxorubicin alone

Design

Preclinical

Follow-up

3 weeks after last dose

Authors

BKBC KotiKLE UniversitySNShweta NagathanKLE UniversityAVA.H.M. VishwanathswamyKLE University

Discussion

Loading...

Member takes

Implication

Should not change doxorubicin management in patients; leaves open translation of Vedic Guard cardioprotection from rat models.

Structured PICO

Does Vedic Guard prevent doxorubicin-induced cardiotoxicity in rats?

P
Population
Rats with doxorubicin-induced cardiotoxicity (15 mg/kg for 2 weeks)
I
Intervention
Vedic Guard (270 mg/kg, orally) administered as pre-treatment for 2 weeks and then for 2 weeks alternated with doxorubicin
C
Comparator
Doxorubicin alone
O
Outcome
Biochemical markers (LDH, CPK, AST, ALT), electrocardiographic (ECG) parameters, histopathology, and antioxidants (GSH, SOD, CAT)surrogate

Vedic Guard demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in rats, likely due to its antioxidant properties.

Cite This Study

Koti et al. (2013) studied this question.

synapsesocial.com/papers/6a7e27f03d987f2790256aa5https://doi.org/10.4103/0973-1296.111287
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between Doxorubicin-Induced Ecg Changes and Myocardial Alterations in Rats1986 · 39 citations
  2. 2Acute and Chronic Cardiovascular Effects of Doxorubicin in the Dog1980 · 172 citations
  3. 3Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals1991 · 111 citations
  4. 4Adriamycin stimulates low-affinity Ca2+ binding and lipid peroxidation but depresses myocardial function1986 · 105 citations
  5. 5Revised Spectrophotometric Methods for the Determination of Glutamic-Oxalacetic Transaminase, Glutamic-Pyruvic Transaminase, and Lactic Acid Dehydrogenase1960 · 684 citations