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December 31, 2024Journal of Cardiovascular Pharmacology

Sodium Glucose Cotransporter 2 Inhibitors Improve Long-term Atrial Fibrillation-free Survival After Catheter Ablation

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Why the study?

Evidence regarding the prognostic effect of SGLT2 inhibitors in patients undergoing catheter ablation for AF is limited.

Does SGLT2i treatment reduce atrial fibrillation recurrence in patients undergoing catheter ablation for atrial fibrillation?

Population

614 patients undergoing catheter ablation for AF at a single center

Comparison

SGLT2i treatment vs non-SGLT2i treatment after index catheter ablation

Design

Single-center retrospective cohort study

Follow-up

24 months

Authors

AHAykun HakgörIstanbul Medipol UniversityFOFatih Erkam OlgunIstanbul Medipol UniversityADAtakan DursunIstanbul Medipol University

Discussion

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Implication

SGLT2i treatment after catheter ablation for atrial fibrillation is associated with a significantly reduced risk of AF recurrence, independent of diabetes or heart failure status.

Structured PICO

Does SGLT2i treatment reduce atrial fibrillation recurrence in patients undergoing catheter ablation for atrial fibrillation?

P
Population
614 patients (mean age 58.1 ± 9.9 years, 42.2% female) who underwent catheter ablation for atrial fibrillation at a single center.
I
Intervention
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) treatment after the index catheter ablation procedure.
C
Comparator
No SGLT2i treatment (non-SGLT2i group).
O
Outcome
Atrial fibrillation recurrence after the first 90-day blanking period after catheter ablation.

SGLT2i treatment after catheter ablation for atrial fibrillation is associated with a significantly reduced risk of AF recurrence, independent of diabetes or heart failure status.

Cite This Study

Hakgör et al. (2024) studied this question.

synapsesocial.com/papers/6a7e2a6d27432f746a32f03bhttps://doi.org/10.1097/fjc.0000000000001656

Topics

Atrial fibrillationPersistent AF managementAF ablation outcomesSGLT2 inhibitors in heart failureAnticoagulation in AF
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Also Consider

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  1. 1Catheter Ablation for Atrial Fibrillation with Heart Failure2018 · 2,519 citations
  2. 22024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)2024 · 2,976 citations
  3. 32017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation2017 · 2,788 citations
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