January 1, 2012Journal of Atherosclerosis and ThrombosisOpen Access

Expression of Endothelial Lipase Correlates with the Size of Neointima in a Murine Model of Vascular Remodeling

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Why the study?

Does endothelial lipase inactivation reduce neointimal lesion size in a murine model of vascular remodeling?

Population

Male endothelial lipase-knockout, EL-transgenic, and wild-type mice subjected to left common carotid artery…

Comparison

Endothelial lipase gene knockout or transgenic… vs Wild-type (WT) mice

Design

Preclinical

Follow-up

14 and 28 days

Authors

LSLi SunNanjing University of Chinese Medicine TITatsuro IshidaHyogo University of Health Sciences TOTakeaki OkadaKobe University

Discussion

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Implication

Endothelial lipase inactivation attenuated neointimal formation in mice; hypothesis-generating for vascular remodeling therapies pending human studies.

Structured PICO

Does endothelial lipase inactivation reduce neointimal lesion size in a murine model of vascular remodeling?

Population

Male endothelial lipase-knockout (ELKO), EL-transgenic (ELTg), and wild-type (WT) mice (C57Bl/6 background, 8 weeks old) subjected to left common carotid artery ligation, as well as cultured vascular smooth muscle cells and human endothelial EA.hy926 cells.

Intervention

Endothelial lipase (EL) gene knockout (ELKO) or transgenic overexpression (ELTg)

Comparator

Wild-type (WT) mice

Outcome

Size of neointimal lesion at 14 and 28 days post-carotid ligationsurrogate

Endothelial lipase inactivation increases HDL particles and attenuates neointimal formation in a murine model of vascular remodeling, suggesting a potential therapeutic target for vascular diseases.

Cite This Study

Sun et al. (2012) studied this question.

synapsesocial.com/papers/6a7e2ec2e6c31702d43ba199 https://doi.org/10.5551/jat.13110

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Implication

Endothelial lipase inactivation attenuated neointimal formation in mice; hypothesis-generating for vascular remodeling therapies pending human studies.

Expression of Endothelial Lipase Correlates with the Size of Neointima in a Murine Model of Vascular Remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of Endothelial Lipase Correlates with the Size of Neointima in a Murine Model of Vascular Remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider