Population
Normal peripheral blood monocytes and T lymphocytes (in vitro model)
Comparison
Co-culture with autologous T lymphocytes vs Cultured in the absence of T lymphocytes
Design
Preclinical
Authors
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Monocyte subset differences in ACE induction remain hypothesis-generating in animal models; human studies needed before any sarcoidosis relevance.
Monocytes are heterogeneous in their ability to be induced by T lymphocytes to synthesize ACE, which may explain elevated ACE synthesis in sarcoidosis granulomas.
Ryu et al. (1992) studied this question.
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