Key result
Dexamethasone augments monocyte angiotensin-converting enzyme (ACE) activity in a biphasic dose-dependent manner with maximum effect at 10(-8) M concentration.
Population
Human monocytes
Comparison
Dexamethasone (various concentrations, max… vs Unstimulated monocytes
Design
Preclinical
Authors
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Dexamethasone may alter monocyte ACE in treated patients; leaves open in vivo cardiovascular relevance.
Dexamethasone specifically induces membrane-bound ACE activity in human monocytes in a dose-dependent manner, likely through increased enzyme synthesis.
Vuk-Pavlović et al. (1989) studied this question. Dexamethasone vs. Unstimulated monocytes was evaluated on Angiotensin-converting enzyme (ACE) activity. Dexamethasone augments monocyte angiotensin-converting enzyme (ACE) activity in a biphasic dose-dependent manner with maximum effect at 10(-8) M concentration.
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