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July 18, 2022Evidence-based Complementary and Alternative MedicineOpen Access

Network Pharmacology and Molecular Docking on the Molecular Mechanism of Jiawei-Huang Lian-Gan Jiang Decoction in the Treatment of Colorectal Adenomas

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Why the study?

JWHLGJD was developed to treat and prevent colorectal adenomas in China, but its active compounds and mechanisms remained to be discovered.

Design

Network pharmacology and molecular docking study

Authors

SJShuangshuang JiSLSidan LongYYYang Yang

Discussion

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Overview

Identifies candidate targets for JWHLGJD in CRA; hypothesis-generating and requires human validation before clinical consideration.

Structured PICO

P
Population
Computational models and databases for colorectal adenomas (CRA)
I
Intervention
Jiawei-Huang Lian-Gan Jiang decoction (JWHLGJD) active compounds
O
Outcome
Active compounds, target genes, and molecular pathwayssurrogate

Network pharmacology and molecular docking identified key active compounds (berberine, stigmasterol) and targets (TP53, MAPK1) for JWHLGJD in treating colorectal adenomas.

Cite This Study

Ji et al. (2022) studied this question.

synapsesocial.com/papers/6a7e3b091bf3cbbc304f99fehttps://doi.org/10.1155/2022/8211941
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Also Consider

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  3. 3Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer2024 · 6 citations
  4. 4Exploring the Potential Pharmacological Basis and Mechanism of HJT Activity in the Treatment of CHD Based on UPLC-QE-MS and Network Pharmacology2024
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