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December 2, 2022MedicineOpen Access

A network pharmacology study of mechanism and efficacy of Jiawei Huanglian-Wendan decoction in polycystic ovary syndrome with insulin resistance

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Why the study?

Polycystic ovary syndrome is commonly accompanied by insulin resistance, but its specific pathogenesis remains unclear, prompting investigation into the efficacy and mechanism of Jiawei Huanglian-Wendan decoction.

Does Jiawei Huanglian-Wendan decoction improve clinical syndromes and metabolic markers in patients with polycystic ovary syndrome and insulin resistance?

Population

Patients with polycystic ovary syndrome with insulin resistance

Comparison

Jiawei Huanglian-Wendan decoction

Design

Network pharmacology study with clinical validation

Authors

NSNa ShiPeople's Liberation Army 401 HospitalYZYuhe ZhouXinjiang Agricultural UniversityHMHongbo Ma

Discussion

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Implication

May support JHWD evaluation in PCOS-IR; hypothesis-generating and requires RCTs before practice change.

Structured PICO

Does Jiawei Huanglian-Wendan decoction improve clinical syndromes and metabolic markers in patients with polycystic ovary syndrome and insulin resistance?

P
Population
Patients with polycystic ovary syndrome (PCOS) with insulin resistance (IR)
I
Intervention
Jiawei Huanglian-Wendan decoction (JHWD)
O
Outcome
Traditional Chinese medicine syndrome score, rate of resumption of normal menstrual cycles and regular ovulation, blood lipid levels, blood glucose and insulin levels, and inflammatory cytokinessurrogate

Network pharmacology and clinical validation suggest that Jiawei Huanglian-Wendan decoction may regulate glycolipid metabolism, reduce insulin resistance, and exert anti-inflammatory effects in PCOS with IR.

Cite This Study

Shi et al. (2022) studied this question.

synapsesocial.com/papers/6a83a3cc4f77243e16b0523bhttps://doi.org/10.1097/md.0000000000032057
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