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April 14, 2023MedicineOpen Access

Modified Huanglian Wendan decoction targets 155 genes, including TNF and HIF-1, in PCOS.

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Why the study?

The molecular mechanism of modified Huanglian Wendan decoction in the intervention of polycystic ovary syndrome needed investigation.

Design

Network pharmacology and molecular docking study

Key result

Modified Huanglian Wendan decoction targets 155 intersection genes and 54 enriched pathways, including TNF and HIF-1, in the treatment of polycystic ovary syndrome.

Authors

ZWZhaojing WuTYTiantian YangHMHongbo Ma

Discussion

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Overview

Does not support clinical use in PCOS; leaves open prospective validation of identified pathways.

Structured PICO

P
Population
Polycystic ovary syndrome (PCOS) targets and ingredients of modified Huanglian Wendan decoction
I
Intervention
Modified Huanglian Wendan decoction (computational analysis)
O
Outcome
Molecular targets, pathways, and docking stabilitysurrogate

Network pharmacology and molecular docking identified potential active ingredients and targets of modified Huanglian Wendan decoction for PCOS.

Cite This Study

Wu et al. (2023) studied polycystic ovary syndrome (PCOS). modified Huanglian Wendan decoction was evaluated on mechanism of action and intersection targets. Modified Huanglian Wendan decoction targets 155 intersection genes and 54 enriched pathways, including TNF and HIF-1, in the treatment of polycystic ovary syndrome.

synapsesocial.com/papers/6aa91a23fdb234f110eca158https://doi.org/10.1097/md.0000000000033212
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A network pharmacology study of mechanism and efficacy of Jiawei Huanglian-Wendan decoction in polycystic ovary syndrome with insulin resistance2022 · 17 citations
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  3. 3The mechanism of Leonuri Herba in improving polycystic ovary syndrome was analyzed based on network pharmacology and molecular docking2023 · 11 citations
  4. 4Identification of CA2 as a Potential Candidate Gene Involved in the Therapeutic Effect of Huatan Huoxue Decoction on Polycystic Ovary Syndrome: An Integrated Study of Network Pharmacology, Mendelian Randomization, and Experimental Validation2026
  5. 5Network pharmacology-based investigation of potential targets of mulberry twig acting on polycystic ovary syndrome2025