The Ovaries Attenuate the Aggravating Effect of Testosterone on Glomerular Injury in Adriamycin-lnduced Nephropathy of Female Rats

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Population

Female Sprague-Dawley rats with Adriamycin-induced nephropathy

Comparison

Testosterone injected subcutaneously every 4… vs Female control rats, male control rats, and…

Design

Preclinical

Follow-up

24 weeks after the second ADR injection

Authors

Discussion

Hypothesis-generating for ovarian-testosterone interactions in rat nephropathy; leaves open any relevance to human CKD.

Population

Female Sprague-Dawley rats with Adriamycin (ADR)-induced nephropathy (ADR 2 mg/kg administered intravenously twice)

Intervention

Testosterone injected subcutaneously every 4 weeks from 5 weeks of age, with or without ovariectomy (OVX) at 5 weeks of age

Comparator

Female control rats, male control rats, and female rats with ovariectomy alone

Outcome

Glomerular injury assessed morphologically 24 weeks after the second ADR injectionsurrogate

In a rat model of Adriamycin-induced nephropathy, the presence of ovaries attenuates the aggravating effect of testosterone on glomerular injury.

Sakemi et al. (1997) studied this question.

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