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November 27, 2012PLoS ONEOpen Access

Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model

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Why the study?

Does transcriptome profiling of peripheral blood mononuclear cells identify potential biomarkers for doxorubicin cardiotoxicity in a rat model?

Population

17 female Sprague-Dawley rats

Comparison

Doxorubicin 12 mg/kg single dose intraperitoneal… vs Saline 0.1 ml single dose intraperitoneal…

Design

Preclinical, Rats were randomized into 2 groups

Follow-up

48 hours

Authors

VTValentina K. TodorovaCentral Arkansas Veterans Healthcare SystemMBMarjorie L. BeggsArkana LaboratoriesRDRobert R. DelongchampUniversity of Arkansas for Medical Sciences

Discussion

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Overview

May support PBMC transcriptome as noninvasive surrogate for doxorubicin cardiotoxicity; leaves open translation from rat model to humans.

Structured PICO

Does transcriptome profiling of peripheral blood mononuclear cells identify potential biomarkers for doxorubicin cardiotoxicity in a rat model?

P
Population
17 female Sprague-Dawley rats
I
Intervention
Doxorubicin 12 mg/kg single dose intraperitoneal injection
C
Comparator
Saline 0.1 ml single dose intraperitoneal injection
O
Outcome
Differentially regulated genes (DRG) in hearts and peripheral blood mononuclear cells (PBMCs) at 48 hourssurrogate

The high similarity between doxorubicin-induced gene expression profiles in the heart and PBMCs suggests that the PBMC transcriptome may serve as a noninvasive surrogate marker for doxorubicin-induced cardiotoxicity.

Cite This Study

Todorova et al. (2012) studied this question.

synapsesocial.com/papers/6a7e3e56567bd3ec6fb7afe5https://doi.org/10.1371/journal.pone.0048398
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