Why the study?
Acute kidney injury is a prevalent condition with serious consequences and limited therapies, highlighting the need to explore nonpharmacological modulation of neuroimmune interactions like ultrasound.
Does pulsed ultrasound treatment improve outcomes in acute kidney injury and other inflammatory conditions?
Does pulsed ultrasound treatment improve outcomes in acute kidney injury and other inflammatory conditions?
Pulsed ultrasound represents a promising noninvasive strategy for treating acute kidney injury and other inflammatory conditions by modulating neuroimmune interactions.
Pulsed ultrasound may offer noninvasive AKI protection; leaves open clinical outcome improvements in inflammatory conditions.
Acute kidney injury (AKI) is an important clinical disorder with high prevalence, serious consequences, and limited therapeutic options. Modulation of neuroimmune interaction by nonpharmacological methods is emerging as a novel strategy for treating inflammatory diseases, including AKI. Recently, pulsed ultrasound (US) treatment was shown to protect from AKI by stimulating the cholinergic anti-inflammatory pathway. Because of the relatively simple, portable, and noninvasive nature of US procedures, US stimulation may be a valuable therapeutic option for treating inflammatory conditions. This review discusses potential impacts of US bioeffects on the nervous system and how this may generate feedback onto the immune system. We also discuss recent evidence supporting the use of US as a means to treat AKI and other inflammatory diseases.
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Cai et al. (2020) studied this question.
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