Why the study?
Heart failure following myocardial infarction represents a major health burden, but underlying microstructural and functional changes remain incompletely understood.
High-dose isoproterenol can induce irreversible myocardial infarction and severe microstructural disarray in mice, which can be detailed using emerging imaging technologies like DT-MRI.
Although heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol (ISO) in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultra-high frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatial resolution of 100×100×100 μm3 using diffusion tensor magnetic resonance imaging (DT-MRI) and histopathologic analyses. Two weeks after ISO-treatment, the animal showed an apical aneurysm accompanied by reduced radial strain in corresponding segments and impaired global systolic function. DT-MRI revealed a loss of contractile fiber tracts together with a disarray of remaining fibers as corresponding microstructural correlates. This pre-clinical case report provides valuable insights into pathophysiology and morphologic-functional relations of heart failure following MI using emerging imaging technologies.
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Beyhoff et al. (2020) studied this question.
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