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Following myocardial infarction, the failure of excitation-contraction coupling—specifically the reduced ability of calcium current to trigger sarcoplasmic reticulum calcium release—is a major contributor to contractile dysfunction and heart failure, a defect that can be alleviated by cardiotonic steroids like ouabain. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 7, 2001CirculationOpen Access

Heart Failure After Myocardial Infarction

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Authors

AGAna M. GómezElectrophysiology SGSílvia GuatimosimElectrophysiology KDKeith W. DillyNovartis (United States)

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Implication

Cardiomyocyte Ca²⁺ defects underlie overt post-MI HF in rats; extends cellular mechanisms but leaves clinical translation open.

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Gómez et al. (2001) studied this question.

synapsesocial.com/papers/6a1a8f7fe916fa6dd3b8bdae https://doi.org/10.1161/hc3201.092285

Topics

Heart failure HFrEF treatment Heart failure hospitalization

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Heart Failure After Myocardial Infarction

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Cite This Study

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Heart Failure After Myocardial Infarction

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Implication

Key Points

Cite This Study

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