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July 1, 1993Journal of Clinical InvestigationOpen Access

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

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Authors

JQJawaid QuddusMayo ClinicKJK J JohnsonThe Ohio State University Wexner Medical CenterJGJerrie GavalchinCornell University

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Quddus et al. (1993) studied this question.

synapsesocial.com/papers/6a7e499bdea41f5fbab7b1bbhttps://doi.org/10.1172/jci116576
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis1990 · 119 citations
  2. 2Biological Effects of 5-Azacytidine in Eukaryotes2009 · 203 citations
  3. 3Lupus prone (SWR x NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent.1985 · 107 citations
  4. 4Effect of an inhibitor of DNA methylation on T cells. I. 5-Azacytidine induces T4 expression on T8+ T cells.1986 · 47 citations