Why the study?
Is ST-elevation myocardial infarction (STEMI) associated with higher on-treatment platelet reactivity following a 600 mg loading dose of clopidogrel compared to other forms of ACS in patients undergoing PCI?
Population
833 patients undergoing percutaneous coronary intervention on clopidogrel, with 58.7% admitted for an acute…
Comparison
Clopidogrel 600 mg loading dose vs Patients with other forms of acute coronary…
Design
Cohort
Authors
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STEMI may warrant potent P2Y12 inhibitors over clopidogrel; this association leaves open the need for randomized outcome trials.
Is ST-elevation myocardial infarction (STEMI) associated with higher on-treatment platelet reactivity following a 600 mg loading dose of clopidogrel compared to other forms of ACS in patients undergoing PCI?
A 600 mg loading dose of clopidogrel is associated with high on-treatment platelet reactivity in STEMI patients, suggesting that more potent P2Y12 inhibitors may be preferred to achieve optimal platelet inhibition.
Berbis et al. (2012) studied this question.
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