Why the study?
Does doxorubicin therapy administered weekly reduce anthracycline-induced endomyocardial injury in patients with malignancy compared to a conventional 3-weekly schedule?
Population
125 patients with malignancy receiving doxorubicin therapy undergoing endomyocardial biopsy.
Comparison
Doxorubicin therapy administered on a weekly… vs Doxorubicin therapy administered once every 3…
Design
Cohort
Authors
Loading...
Weekly doxorubicin may reduce myocardial injury; hypothesis-generating and should not yet change practice without randomized confirmation.
Does doxorubicin therapy administered weekly reduce anthracycline-induced endomyocardial injury in patients with malignancy compared to a conventional 3-weekly schedule?
Administering doxorubicin on a weekly schedule rather than the conventional 3-weekly schedule significantly reduces anthracycline-induced endomyocardial damage.
Frank M. Torti (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: