Key result
Elevated oxidative stress links cardiovascular disease to shared pathways in prostatic disease development.
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Reveals that oxidative stress connects cardiovascular and prostatic diseases during aging, suggesting shared pathological pathways offer potential therapeutic targets.
The incidence of chronic aging-associated diseases, especially cardiovascular and prostatic diseases, is increasing with the aging of society. Evidence indicates that cardiovascular diseases usually coexist with prostatic diseases or increase its risk, while the pathological mechanisms of these diseases are unknown. Oxidative stress plays an important role in the development of both cardiovascular and prostatic diseases. The levels of oxidative stress biomarkers are higher in patients with cardiovascular diseases, and these also contribute to the development of prostatic diseases, suggesting cardiovascular diseases may increase the risk of prostatic diseases via oxidative stress. This review summarizes the role of oxidative stress in cardiovascular and prostatic diseases and also focuses on the main shared pathways underlying these diseases, in order to provide potential prevention and treatment targets.
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Zhao et al. (2021) conducted a review in Aging-associated cardiovascular and prostatic diseases. Oxidative stress was evaluated. Oxidative stress biomarkers are elevated in cardiovascular disease patients and contribute to shared pathways driving prostatic disease development.
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