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February 28, 2025Frontiers in ImmunologyOpen Access

Pyrvinium pamoate significantly suppressed M.tb-induced NLRP3 inflammasome activation, GSDMD-mediated pyroptosis, and inflammatory cytokine expression in a dose-dependent manner, and inhibited intracellular M.tb survival.

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Why the study?

The potential mechanism of pyrvinium pamoate for inhibiting Mycobacterium tuberculosis-induced inflammation remained unexplored.

Does pyrvinium pamoate suppress NLRP3 inflammasome activation and pyroptosis in mycobacteria-infected human macrophages?

Population

Human THP-1-derived macrophages infected with M.tb, S. typhimurium, or treated with LPS

Comparison

Pyrvinium pamoate treatment vs control

Design

In vitro laboratory study

Authors

QGQing GuanHXHuan XiongXSXiangyu Song

Discussion

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Member takes

Overview

Pyrvinium pamoate merits exploration as TB host-directed therapy; leaves open translation from animal models to human efficacy.

Structured PICO

Does pyrvinium pamoate suppress NLRP3 inflammasome activation and pyroptosis in mycobacteria-infected human macrophages?

P
Population
Human THP-1-derived macrophages infected with Mycobacterium tuberculosis (H37Rv/H37Ra), Salmonella typhimurium, or treated with LPS
I
Intervention
Pyrvinium pamoate (PP) at concentrations of 1-5 µg/ml for 24 hours
C
Comparator
Untreated or DMSO-treated infected/stimulated macrophages
O
Outcome
NLRP3-ASC-Casp1 inflammasome assembly and activation, GSDMD-mediated pyroptosis, and inflammatory cytokines (IL-1β and IL-18) expressionsurrogate

Pyrvinium pamoate suppresses mycobacteria-induced NLRP3 inflammasome activation and pyroptosis by targeting CK1α pathways, suggesting potential as a host-directed therapy for tuberculosis.

Cite This Study

Guan et al. (2025) studied this question.

synapsesocial.com/papers/6a7e5407cc2a0d08ea85637bhttps://doi.org/10.3389/fimmu.2025.1553093
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>Mycobacterium tuberculosis</i> does not inhibit NLRP1 and pyrin inflammasomes in human macrophages2026
  2. 2Chlojaponilactone B Attenuates THP-1 Macrophage Pyroptosis by Inhibiting the TLR/MyD88/NF-κB Pathway2024 · 10 citations
  3. 3Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes <i>Mycobacterium tuberculosis</i> Survival2025
  4. 4<i>Mycobacterium tuberculosis</i> Utilizes Serine/Threonine Kinase PknF to Evade NLRP3 Inflammasome-driven Caspase-1 and RIPK3/Caspase-8 Activation in Murine Dendritic Cells2024 · 2 citations
  5. 5NLRP3 inflammasome and pyroptosis: implications in inflammation and multisystem disorders2025 · 20 citations