What question did this study set out to answer?

To test whether dietary soy attenuates the development of hypertension in female spontaneously hypertensive rats with and without ovarian hormone deficiency.

August 1, 2001AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats

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Authors

DMDoug MartinUniversity of Utah Hospital NBN. P. Breitkopf KEKathleen M. EysterUniversity of South Dakota

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Implication

Randomized trial demonstrates that dietary soy reduces blood pressure in ovariectomized hypertensive rats, suggesting blood pressure control mediated by the autonomic nervous system.

Key Points

To test whether dietary soy attenuates the development of hypertension in female spontaneously hypertensive rats with and without ovarian hormone deficiency.
Four-week-old female spontaneously hypertensive rats and control Wistar-Kyoto rats were randomly assigned to either ovariectomy or sham surgery.
Animals were maintained on either a soy diet or a casein control diet for at least 8 weeks.
Mean arterial pressure and heart rate were recorded at baseline and following nitric oxide synthase inhibition, air-jet stress, or ganglionic blockade.
Mean arterial pressure was lower in ovariectomized hypertensive rats fed soy compared to casein-fed controls (150 ± 4 vs. 164 ± 3 mmHg).
Plasma genistein concentrations reached 1.23 ± 0.31 µM in soy-fed ovariectomized rats (undetectable in casein-fed controls) and 1.37 ± 0.42 µM in sham-operated soy-fed rats.
Nitric oxide synthase inhibition increased mean arterial pressure across all groups equally, but ganglionic blockade completely eliminated the antihypertensive effect of dietary soy.

Cite This Study

Martin et al. (2001) studied this question.

synapsesocial.com/papers/6a7e575e2fd85368b24d8f47 https://doi.org/10.1152/ajpregu.2001.281.2.r553

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Implication

Randomized trial demonstrates that dietary soy reduces blood pressure in ovariectomized hypertensive rats, suggesting blood pressure control mediated by the autonomic nervous system.

Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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