Why the study?
Do ACE inhibitors or AT1-receptor antagonists restore NOS activity and neuronal NOS expression in the adrenal glands of spontaneously hypertensive rats?
Population
Spontaneously hypertensive (SHR) rats and Wistar-Kyoto (WKY) rats at ages 3-4, 7-8, and 12-13 weeks
Comparison
Captopril, enalapril, or losartan for 10 days vs Control rats
Design
Preclinical
Follow-up
10 days
Authors
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May contribute to antihypertensive effects in SHR models; hypothesis-generating and should not change practice.
Do ACE inhibitors or AT1-receptor antagonists restore NOS activity and neuronal NOS expression in the adrenal glands of spontaneously hypertensive rats?
ACE inhibitors and AT1-receptor antagonists restore impaired NO synthesis and upregulate nNOS protein in the adrenal glands of spontaneously hypertensive rats, which may contribute to their antihypertensive effects.
Qadri et al. (2001) studied this question.
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