Key result
nNOS mRNA expression in the adrenal gland was 2.5 times higher in 24-week-old WKY rats than in age-matched SHR, and was upregulated by antihypertensive treatments including TCV-116 and hydralazine.
Why the study?
Does antihypertensive treatment alter nNOS expression in the adrenal medulla of hypertensive and normotensive rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)
Comparison
Antihypertensive treatment with angiotensin II… vs Untreated SHR and WKY rats
Design
Preclinical
Authors
Loading...
Antihypertensive treatment may modulate adrenal nNOS in rat models; leaves open any role in human hypertension.
Does antihypertensive treatment alter nNOS expression in the adrenal medulla of hypertensive and normotensive rats?
Antihypertensive treatment upregulates nNOS expression in the adrenal medulla of rats, suggesting a link between nNOS and the sympathoadrenal system in hypertension.
Iwai et al. (1995) studied Hypertension. Antihypertensive treatment (TCV-116, hydralazine, or reserpine) vs. Untreated / WKY vs SHR was evaluated on nNOS mRNA expression levels. nNOS mRNA expression in the adrenal gland was 2.5 times higher in 24-week-old WKY rats than in age-matched SHR, and was upregulated by antihypertensive treatments including TCV-116 and hydralazine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: