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January 1, 2024Wiadomości Lekarskie

Effect of ivabradine on structural and functional changes of myocardium and NT-proBNP levels in patients with stable coronary heart disease after coronary stenting

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Why the study?

The study evaluated the effect of ivabradine on hemodynamics, myocardial contractility, and NT-proBNP production according to the number of affected coronary arteries in patients with stable ischemic heart disease after endovascular revascularization.

Does ivabradine improve myocardial structural and functional parameters and NT-proBNP levels in patients with stable coronary heart disease and heart failure after coronary stenting?

Population

120 patients with stable CAD and HF after coronary artery stenting

Comparison

Ivabradine vs control

Design

Randomized study

Follow-up

12 months

Authors

IKIryna KupnovytskaIvano-Frankivsk National Medical UniversityNRN.M. RomanyshynIFI.P. Fitkovska

Discussion

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Implication

Ivabradine effects post-revascularization by vessel count remain preliminary; leaves open need for randomized confirmation on hemodynamics and NT-proBNP.

Structured PICO

Does ivabradine improve myocardial structural and functional parameters and NT-proBNP levels in patients with stable coronary heart disease and heart failure after coronary stenting?

P
Population
120 patients with stable coronary artery disease (angina pectoris functional class III) and heart failure (stage IIA, functional class III) with preserved and moderately reduced left ventricular ejection fraction, who underwent coronary artery stenting.
I
Intervention
Ivabradine added to standard therapy for 12 months
C
Comparator
Standard therapy alone
O
Outcome
Structural and functional parameters of the myocardium (hemodynamics, contractility, reverse remodeling) and NT-proBNP levels at 12 monthssurrogate

In patients with stable coronary artery disease and heart failure with preserved or moderately reduced ejection fraction after stenting, adding ivabradine to standard therapy improves left ventricular reverse remodeling at 12 months.

Cite This Study

Kupnovytska et al. (2024) studied this question.

synapsesocial.com/papers/6a7e59f2dea41f5fbab7b4d9https://doi.org/10.36740/wlek202404128

Topics

Coronary artery disease
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