Why the study?
Does a supplemental dose of IPV improve immunogenicity against poliovirus type 3 compared to OPV in infants who previously received OPV?
Population
1025 infants at nine months of age who had previously received five doses of oral poliovirus vaccine (OPV)
Comparison
Supplemental dose of inactivated-poliovirus… vs Supplemental dose of trivalent OPV or monovalent…
Design
RCT, randomly assigned
Follow-up
30 days
Authors
Loading...
Supports supplemental IPV for type 3 boosting in OPV-primed infants; confirms immunogenicity superiority versus additional OPV.
Does a supplemental dose of IPV improve immunogenicity against poliovirus type 3 compared to OPV in infants who previously received OPV?
A supplemental dose of IPV, but not OPV, significantly increases immunogenicity against type 3 poliovirus in infants who previously received multiple doses of OPV.
Sutter et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: