Key result
Post-stroke hyperthermia is linked to worse clinical outcomes, reduced treatment efficacy, and expanded infarction.
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Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.
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Wang et al. (2009) conducted a review in Ischaemic brain injury / Stroke. Hyperthermia vs. Normothermic conditions was evaluated on Clinical outcome and conversion of salvageable penumbra to ischaemic infarct. Hyperthermia in stroke negatively correlates with clinical outcome, impairs treatment efficacy, and converts salvageable penumbra to ischaemic infarct.
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