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October 1, 1999Journal of Hypertension

Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure

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Why the study?

Is the eNOS gene linked to physiological variation of blood pressure in healthy families?

Population

260 healthy volunteer families comprising mother and father and two natural offspring from the Victorian…

Design

Cross-sectional

Authors

STSeiju TakamiThe University of OsakaZWZilla Y. H. WongUniversity of LeicesterMSMargaret Susanne StebbingThe University of Melbourne

Discussion

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Implication

No linkage to BP phenotypes in healthy families; leaves open eNOS role in hypertension or other populations.

Structured PICO

Is the eNOS gene linked to physiological variation of blood pressure in healthy families?

P
Population
260 healthy volunteer families comprising mother and father (aged 40-70 years) and two natural offspring (aged 18-30 years) from the Victorian Family Heart Study (total n=1040)
I
Intervention
Genotyping at five microsatellite loci including the CA repeat in the eNOS gene on chromosome 7q35-36
O
Outcome
Linkage with systolic and diastolic blood pressure, mean arterial pressure, and pulse pressuresurrogate

The eNOS gene is not linked to physiological variation of blood pressure or related phenotypes in this healthy population.

Cite This Study

Takami et al. (1999) studied this question.

synapsesocial.com/papers/6a7e65d8b44705ee46856c48https://doi.org/10.1097/00004872-199917100-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood pressure, systolic and diastolic, and cardiovascular risks. US population data1993 · 1,221 citations
  2. 2Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese1997 · 82 citations
  3. 3Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension1998 · 525 citations
  4. 4Elevated blood pressures in mice lacking endothelial nitric oxide synthase1996 · 907 citations
  5. 5Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.1994 · 397 citations