What question did this study set out to answer?

To evaluate whether dietary intake and serum 25-hydroxyvitamin D concentrations predict the incidence and structural progression of knee osteoarthritis.

September 1, 1996Annals of Internal Medicine

Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study

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Authors

TMT.E. McAlindonUniversity of Massachusetts Chan Medical School

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Implication

A prospective observational study observes that low vitamin D intake and serum levels increase knee osteoarthritis progression risk in older adults, suggesting a protective role for bone health.

Key Points

To evaluate whether dietary intake and serum 25-hydroxyvitamin D concentrations predict the incidence and structural progression of knee osteoarthritis.
Prospective observational study tracking 556 Framingham Study participants (mean age 70.3 ± 4.5 years) with bilateral knee radiography performed at examination 18 (1983–1985) and examination 22 (1992–1993).
Vitamin D dietary intake (via food and supplement questionnaires) and serum 25-hydroxyvitamin D concentrations were assessed at examination 20 (1988–1989).
Knee radiographs were scored for global osteoarthritis severity using a modified Kellgren-Lawrence scale, joint-space narrowing, and osteophyte growth, adjusting for age, sex, body mass index, weight change, and bone mineral density.
Progressive knee osteoarthritis occurred in 62 knees, with risk increasing for participants in the lowest versus highest tertile of vitamin D intake (OR 4.0; 95% CI, 1.4 to 11.6) and serum vitamin D (OR 2.9; 95% CI, 1.0 to 8.2).
Low serum vitamin D levels independently predicted joint-space narrowing (OR 2.3; 95% CI, 0.9 to 5.5) and osteophyte growth (OR 3.1; 95% CI, 1.3 to 7.5).
Incident knee osteoarthritis occurred in 75 knees but showed no consistent association with dietary intake or serum levels of vitamin D.

Cite This Study

T.E. McAlindon (1996) studied this question.

synapsesocial.com/papers/6a7e68cd27432f746a32f637 https://doi.org/10.7326/0003-4819-125-5-199609010-00001

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Implication

A prospective observational study observes that low vitamin D intake and serum levels increase knee osteoarthritis progression risk in older adults, suggesting a protective role for bone health.

Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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