May 1, 1978Circulation Research

The effect of an increase in inotropic state and end-diastolic volume on the pumping ability of the feline left heart.

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Population

Isolated ejecting cat hearts

Comparison

Changes in inotropic state and ventricular… vs Control beats at the same end-diastolic pressure

Design

Preclinical

Authors

GEG ElzingaUniversity of Amsterdam NWNicolaas WesterhofBrooke Army Medical Center

Discussion

Member takes

Implication

Facilitates quantitative modeling of ventricular performance in isolated hearts; leaves open translation to intact human physiology and practice.

Structured PICO

Population

Isolated ejecting cat hearts

Intervention

Changes in inotropic state and ventricular end-diastolic volume (ejecting against a series of different loads)

Comparator

Control beats at the same end-diastolic pressure

Outcome

Left ventricular mean pressure-mean output relationshipsurrogate

In isolated cat hearts, changes in cardiac pumping ability due to altered inotropic state and end-diastolic volume can be mathematically quantified using multiplication factors applied to the mean pressure-mean output relationship.

Cite This Study

Elzinga et al. (1978) studied this question.

synapsesocial.com/papers/6a7e6b977ddcd43fa24f9cfd https://doi.org/10.1161/01.res.42.5.620

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Implication

Facilitates quantitative modeling of ventricular performance in isolated hearts; leaves open translation to intact human physiology and practice.

The effect of an increase in inotropic state and end-diastolic volume on the pumping ability of the feline left heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of an increase in inotropic state and end-diastolic volume on the pumping ability of the feline left heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider