Key result
Increasing heart rate from 120 to 160 beats/min caused a parallel shift in the pump function graph, with oxygen consumption decreasing as output increased.
Population
Feline left heart model
Comparison
Change in heart rate from 120 to 160 beats/min… vs Baseline heart rate (120 beats/min)
Design
Preclinical
Authors
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Heart rate effects on feline cardiac efficiency remain hypothesis-generating; leaves open human translation pending further study.
The study demonstrates that in the feline left heart, maximum power output and optimum efficiency occur at different levels of mean output, and heart rate changes shift the pump function curve.
Elzinga et al. (1980) studied Feline left heart pump function. Change in heart rate from 120 to 160 beats/min and arterial load vs. 120 beats/min was evaluated on Pump function (relationship between mean left ventricular pressure and mean left ventricular output). Increasing heart rate from 120 to 160 beats/min caused a parallel shift in the pump function graph, with oxygen consumption decreasing as output increased.
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