Why the study?
Does doxorubicin alter human myocardial nuclear morphology, and does N-acetylcysteine prevent these changes?
Population
32 patients undergoing endomyocardial biopsy
Comparison
Doxorubicin administration with or without… vs Pre-treatment baseline and idiopathic congestive…
Design
Cohort
Follow-up
4 and 24 hours for acute treatment groups
Authors
Loading...
Acute doxorubicin nuclear changes appear NAC-independent; leaves open their predictive value for clinical cardiotoxicity.
Does doxorubicin alter human myocardial nuclear morphology, and does N-acetylcysteine prevent these changes?
Doxorubicin induces rapid, transient morphological changes in human myocardial nuclei that are not prevented by N-acetylcysteine, with chronic exposure leading to distinct chromatin clumping.
Unverferth et al. (1983) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: