Why the study?
The molecular pathogenesis of AF remains largely unclear, and reported findings on individual miRNA expression signatures across contemporary studies are inconsistent.
What are the differentially expressed miRNA biomarkers in subjects with atrial fibrillation compared to those without?
What are the differentially expressed miRNA biomarkers in subjects with atrial fibrillation compared to those without?
This protocol outlines a systematic review and bioinformatics analysis to identify miRNA biomarkers and their biological pathways in atrial fibrillation.
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Protocol for miRNA biomarker discovery in AF leaves open their validation and clinical utility; prospective studies needed.
Shen et al. (2019) studied this question.
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