Why the study?
Does cardiovascular autonomic neuropathy worsen left ventricular diastolic function in normotensive type 1 diabetic patients?
Does cardiovascular autonomic neuropathy worsen left ventricular diastolic function in normotensive type 1 diabetic patients?
Cardiovascular autonomic neuropathy is associated with worse left ventricular diastolic dysfunction in normotensive type 1 diabetic patients, as assessed by tissue Doppler imaging.
May support closer LV monitoring in T1D with CAN; hypothesis-generating, prospective studies needed before practice change.
Cardiovascular autonomic neuropathy (CAN) is one of the most serious complications of diabetes and has been weakly linked with left ventricular (LV) diastolic dysfunction. Previous studies that explored this association either suffer from inadequate definition of CAN or have mainly used conventional Doppler or nuclear techniques to investigate LV diastolic function. Tissue Doppler imaging (TDI) has evolved as a new quantitative tool for the assessment of cardiac systolic function, diastolic function, and the hemodynamics of LV filling. We sought to investigate conventional and TDI-derived indexes of LV systolic and diastolic function in type 1 diabetic patients with and without CAN and also in normal control subjects. Our findings suggest that the presence of CAN seems to have an additive effect on LV diastolic dysfunction in type 1 diabetes.
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Karamitsos et al. (2008) studied this question.
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