Key result
The presence of cardiovascular autonomic neuropathy had an additive effect on left ventricular diastolic dysfunction in normotensive type 1 diabetic patients.
Why the study?
Does cardiovascular autonomic neuropathy worsen left ventricular diastolic dysfunction in normotensive type 1 diabetic patients?
Observational
Does cardiovascular autonomic neuropathy worsen left ventricular diastolic dysfunction in normotensive type 1 diabetic patients?
Cardiovascular autonomic neuropathy exacerbates left ventricular diastolic dysfunction in normotensive patients with type 1 diabetes, as assessed by tissue Doppler imaging.
May warrant autonomic neuropathy screening in normotensive type 1 diabetes; leaves open prospective confirmation of additive diastolic risk.
Cardiovascular autonomic neuropathy (CAN) is one of the most serious complications of diabetes and has been weakly linked with left ventricular (LV) diastolic dysfunction. Previous studies that explored this association either suffer from inadequate definition of CAN or have mainly used conventional Doppler or nuclear techniques to investigate LV diastolic function. Tissue Doppler imaging (TDI) has evolved as a new quantitative tool for the assessment of cardiac systolic function, diastolic function, and the hemodynamics of LV filling. We sought to investigate conventional and TDI-derived indexes of LV systolic and diastolic function in type 1 diabetic patients with and without CAN and also in normal control subjects. Our findings suggest that the presence of CAN seems to have an additive effect on LV diastolic dysfunction in type 1 diabetes.
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Karamitsos et al. (2008) conducted an observational in Normotensive Type 1 Diabetes. Cardiovascular autonomic neuropathy vs. Type 1 diabetic patients without cardiovascular autonomic neuropathy and normal control subjects was evaluated on Conventional and TDI-derived indexes of left ventricular systolic and diastolic function. The presence of cardiovascular autonomic neuropathy had an additive effect on left ventricular diastolic dysfunction in normotensive type 1 diabetic patients.
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