Normal Values and Gender Differences of Left Ventricular Functional Parameters with CardioREPO Software

Background: Gated myocardial perfusion single-photon emission computed tomography (SPECT) has been used to evaluate quantitative cardiac functional parameters using a dedicated software program. The aim of this study was to measure normal values of left ventricular (LV) functional parameters for a cardioREPO software program (cREPO) and to evaluate gender differences in these parameters.Methods: The Japanese normal database consisted of 206 99mTc-sestamibi or 99mTc-tetrofosmin myocardial perfusion SPECT images was used. The RR interval of the electrocardiogram was divided into 16 frames in the gated image. The cREPO can automatically calculate LV ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), peak filling rate, 1/3 mean filling rate (MFR), time to PFR (TTPF) as well as phase histogram parameters of 95% phase bandwidth, phase standard deviation (SD), and entropy.Results: Mean LVEF was slightly higher in females (71.7 vs. 69.6%, p=0.0018), and EDV and ESV were higher in males (92.5 vs. 70.9 mL for EDV, p<0.0001; and 27.5 vs. 19.9 mL for ESV, p<0.0001). Diastolic functions of 1/3 MFR, TTPF, and TTPF/RR interval significantly differed between males and females (1.46 vs. 1.62/sec, p=0.007; 171 vs. 153 ms, p=0.001; and 0.18 vs. 0.17, p=0.028, respectively). Gender differences were observed in 95% bandwidth (43° for males vs. 37° for females, p<0.0001), phase SD (10.6° vs. 9.2°, p<0.0001), and entropy (46% vs. 41%, p<0.0001).Conclusions: Normal mean values of LV functional parameters for cREPO were determined. These normal values for cREPO could be used as a basis for evaluation of a gated SPECT image in patients with cardiac diseases.