Key result
LVEF and LV volumes determined by gated SPECT were significantly affected by gender and age, and reference limits were established using QGS, ECToolbox, and 4D-MSPECT.
Why the study?
The study was conducted to derive sex-specific reference limits for left ventricular functional parameters in patients with low-likelihood coronary heart disease using three quantitative methods and assess the effects of gender, age, and body weight.
What are the sex-specific reference limits for left ventricular functional parameters estimated by gated myocardial perfusion imaging using different quantitative software in patients with low-likelihood coronary heart disease?
Observational (n=175)
What are the sex-specific reference limits for left ventricular functional parameters estimated by gated myocardial perfusion imaging using different quantitative software in patients with low-likelihood coronary heart disease?
LVEF and LV volumes measured by gated SPECT are significantly affected by gender, age, and body weight, and reference limits vary depending on the quantitative software used.
Derives gender- and age-specific LV reference limits in low-likelihood patients; leaves open generalizability and clinical adoption pending validation.
Our aim was to derive male and female reference limits of left-ventricular functional parameters for patients with low-likehood coronary heart disease using three quantitative methods and determined the effect of gender, age and body weight on cardiac functional parameters. One hundred and seventy-five consecutive patients who defined as low-likehood coronary heart disease patients underwent adenosine or exercise stress 99mTc-MIBI gated myocardial perfusion single photon emission computed tomography (SPECT) imaging, left ventricular (LV) ejection fraction (EF)，end-diastolic volume (EDV)，and end-systolic volume (ESV) were obtained by QGS, ECToolbox and 4D-MSPECT, respectively. LVEF and LV volumes determined by gated SPECT are significantly affected by gender and age, with body weight as a significant predictor for cardiac volumes. The values of EDV and EF determined by three methods could be different although they correlate very well; the reference limit of EDV, ESV and EF calculated by three methods are established.
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Li et al. (2024) conducted an observational in Low-likelihood coronary heart disease (n=175). QGS, ECToolbox and 4D-MSPECT software was evaluated on Left ventricular ejection fraction, end-diastolic volume, and end-systolic volume. LVEF and LV volumes determined by gated SPECT were significantly affected by gender and age, and reference limits were established using QGS, ECToolbox, and 4D-MSPECT.
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