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December 24, 2013Public Health Frontier

Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT

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Why the study?

Are 123I-BMIPP and 123I-MIBG cardiac uptakes associated with left ventricular functional parameters and cardiac events in patients with heart disease?

Population

Patients with heart disease and ejection fraction ranging from 16.2% to 82.2%.

Design

Cohort

Follow-up

1177±486 days

Authors

INIchiro NakaeKMKenichi MitsunamiHHHideki Hayashi

Discussion

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Overview

May support risk stratification in heart disease; leaves open prospective validation before clinical adoption.

Structured PICO

Are 123I-BMIPP and 123I-MIBG cardiac uptakes associated with left ventricular functional parameters and cardiac events in patients with heart disease?

P
Population
Patients with heart disease and ejection fraction ranging from 16.2% to 82.2% (n=30 for 123I-BMIPP, n=37 for 123I-MIBG, and n=100 for normal EF ≥50%).
I
Intervention
123I-BMIPP or 123I-MIBG myocardial scintigraphy with quantitative gated SPECT
O
Outcome
Correlation of 123I-BMIPP and 123I-MIBG uptakes with left ventricular functional parameters (EF, 1/3FR, PFR, TPF) and occurrence of cardiac eventssurrogate

Decreased myocardial fatty acid metabolism and cardiac sympathetic nerve inactivity, along with specific diastolic dysfunctions, may indicate poor cardiac prognosis in patients with heart disease.

Cite This Study

Nakae et al. (2013) studied this question.

synapsesocial.com/papers/6a7e74bc567bd3ec6fb7b67ehttps://doi.org/10.5963/phf0204001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure2003 · 9 citations
  2. 2Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function2010 · 93 citations
  3. 3Prediction of outcome in dilated cardiomyopathy.1987 · 181 citations
  4. 4Left ventricular structure and diastolic function with human ageing Relation to habitual exercise and arterial stiffness2003 · 144 citations
  5. 5Diastolic Heart Failure — Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle2004 · 1,556 citations