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February 1, 1999HeartOpen Access

Assessment of myocardial fatty acid metabolic abnormalities in patients with idiopathic dilated cardiomyopathy using 123I BMIPP SPECT: correlation with clinicopathological findings and clinical course

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Why the study?

Does 123I BMIPP SPECT imaging correlate with clinicopathological findings and predict clinical deterioration in patients with idiopathic dilated cardiomyopathy?

Population

32 consecutive patients with idiopathic dilated cardiomyopathy

Design

Cohort

Follow-up

mean (SD) 20 (11) months

Authors

YYY YazakiMIMitsuaki IsobeWTWataru Takahashi

Discussion

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Overview

Supports noninvasive metabolic assessment in idiopathic dilated cardiomyopathy; leaves open incremental prognostic value pending prospective validation.

Structured PICO

Does 123I BMIPP SPECT imaging correlate with clinicopathological findings and predict clinical deterioration in patients with idiopathic dilated cardiomyopathy?

P
Population
32 consecutive patients with idiopathic dilated cardiomyopathy
I
Intervention
Iodine-123 beta-methyl-iodophenyl pentadecanoic acid (123I BMIPP) and thallium-201 myocardial single photon emission computed tomography (SPECT)
O
Outcome
Correlation of 123I BMIPP total score with clinicopathological variables (pulmonary capillary wedge pressure, left ventricular end diastolic pressure, fractional shortening, myocyte diameter, interstitial fibrosis) and prognostic value of mismatches between the two tracerssurrogate

Myocardial fatty acid metabolic abnormalities assessed by 123I BMIPP SPECT correlate with hemodynamic and histopathological severity and predict clinical deterioration in idiopathic dilated cardiomyopathy.

Cite This Study

Yazaki et al. (1999) studied this question.

synapsesocial.com/papers/6a720ed326770c2b8de151ebhttps://doi.org/10.1136/hrt.81.2.153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure2003 · 9 citations
  2. 2Iodine-123 BMIPP scintigraphy in the evaluation of patients with heart failure2006 · 12 citations
  3. 3Discrepancies between myocardial perfusion and free fatty acid metabolism in patients with hypertrophic cardiomyopathy1993 · 25 citations
  4. 4Prognostic Value of <sup>123</sup>I-BMIPP SPECT in Patients with Nonischemic Heart Failure with Preserved Ejection Fraction2017 · 21 citations
  5. 5Association of Iodine-123 BMIPP and MIBG Cardiac Uptakes with Left Ventricular Functional Parameters Assessed by Gated Myocardial Perfusion SPECT2013 · 1 citations