Key result
Right ventricular metabolic index from [123I]-BMIPP and 201Tl scintigraphy showed a significant negative correlation with mean pulmonary arterial pressure and total pulmonary resistance.
Why the study?
Does [123I]-BMIPP myocardial scintigraphy correlate with the degree of right ventricular pressure overload in patients with chronic respiratory and pulmonary vascular disease?
Observational (n=46)
Does [123I]-BMIPP myocardial scintigraphy correlate with the degree of right ventricular pressure overload in patients with chronic respiratory and pulmonary vascular disease?
[123I]-BMIPP myocardial scintigraphy demonstrates that right ventricular fatty-acid metabolism declines as right ventricular pressure overload increases, suggesting its utility in evaluating RV metabolic disorders.
Answers are grounded in this paper and cite their sources.
May aid noninvasive RV assessment in pulmonary vascular disease; leaves open prospective validation before clinical adoption.
The objective of this study was to evaluate whether or not right ventricle (RV) uptake of iodine-123-labelled-β-methyliodophenylpentadecanoic acid ([ 123 I]-BMIPP) correlated with the degree of right ventricular pressure overload (RVPO). Myocardial scintigraphy of [ 123 I]-BMIPP and thallium-201 ( 201 Tl) was performed on 46 patients with RVPO. We determined the right ventricle (RV)/left ventricle (LV) ratio = (radioactivities of RV)/(radioactivities of LV), and the RV metabolic index (RVMI) = (RV/LV ratio of [ 123 I]-BMIPP)/(RV/LV ratio of 201 Tl). We also evaluated the correlation between RVMI and mean pulmonary arterial pressure (mPAP), and between RVMI and total pulmonary resistance (TPR). Significant correlations were found between the RV/LV ratio of [ 123 I]-BMIPP and mPAP and between the RV/LV ratio of [ 123 I]-BMIPP and TPR. In addition, a significant negative correlation was observed between RVMI and mPAP and between RVMI and TPR. RVMI declined as RVPO increased, suggesting the presence of a fatty-acid metabolism disorder of the RV. Moreover, [ 123 I]-BMIPP myocardial scintigraphy could be useful for evaluating a disorder of the fatty-acid metabolism of the RV with RVPO.
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Matsushita et al. (2000) conducted an observational in Right ventricular pressure overload (n=46). [123I]-BMIPP and 201Tl myocardial scintigraphy was evaluated on Correlation between right ventricular metabolic index (RVMI) and mean pulmonary arterial pressure (mPAP) and total pulmonary resistance (TPR). Right ventricular metabolic index from [123I]-BMIPP and 201Tl scintigraphy showed a significant negative correlation with mean pulmonary arterial pressure and total pulmonary resistance.
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