Key result
Patients with hypertrophic cardiomyopathy demonstrated a significantly higher 3-hour myocardial washout rate of 123I-BMIPP compared to healthy controls (26.3% vs 18.3%, P<0.05).
Why the study?
Does myocardial metabolism of free fatty acids, assessed by 123I-BMIPP SPET, differ between patients with hypertrophic cardiomyopathy and healthy controls?
Population
9 patients with hypertrophic cardiomyopathy (HCM) and 8 healthy volunteers
Comparison
Single-photon emission tomography with… vs Healthy volunteers
Design
Case-control
Follow-up
3 hours
Authors
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Suggests altered fatty acid metabolism in HCM; hypothesis-generating for 123I-BMIPP imaging utility.
Case-Control (n=17)
Does myocardial metabolism of free fatty acids, assessed by 123I-BMIPP SPET, differ between patients with hypertrophic cardiomyopathy and healthy controls?
Absolute Event Rate: 26.3% vs 18.3%
p-value: p=<0.05
Patients with hypertrophic cardiomyopathy exhibit inhomogeneous uptake and accelerated washout of the free fatty acid analogue 123I-BMIPP compared to healthy controls, indicating altered myocardial metabolism.
CHEN et al. (1995) conducted a case-control in Hypertrophic cardiomyopathy (n=17). Hypertrophic cardiomyopathy vs. Healthy volunteers was evaluated on 3-hour washout rate of 123I-BMIPP (p=<0.05). Patients with hypertrophic cardiomyopathy demonstrated a significantly higher 3-hour myocardial washout rate of 123I-BMIPP compared to healthy controls (26.3% vs 18.3%, P<0.05).
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