Key result
In patients with hypertrophic cardiomyopathy, decreased 123I-BMIPP uptake compared to delayed 201Tl was observed in 65% of myocardial segments with reversible exercise 201Tl defects (p<0.001).
Why the study?
Does combined exercise 201Tl and rest 123I-BMIPP scintigraphy identify a relationship between myocardial perfusion abnormalities and fatty acid metabolic abnormalities in patients with hypertrophic cardiomyopathy?
Population
28 patients with hypertrophic cardiomyopathy (HCM)
Design
Cross-sectional
Authors
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Reversible ischemia linked to metabolic abnormalities in HCM; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=28)
Does combined exercise 201Tl and rest 123I-BMIPP scintigraphy identify a relationship between myocardial perfusion abnormalities and fatty acid metabolic abnormalities in patients with hypertrophic cardiomyopathy?
p-value: p=<0.001
Exercise-induced myocardial ischemia in hypertrophic cardiomyopathy is associated with fatty acid metabolic abnormalities, as demonstrated by combined 123I-BMIPP and 201Tl scintigraphy.
Matsuo et al. (1998) conducted an observational in Hypertrophic cardiomyopathy (n=28). Exercise 201Tl and rest 123I-BMIPP scintigraphy was evaluated on Decreased 123I-BMIPP uptake compared with delayed 201Tl in myocardial segments with reversible exercise 201Tl defects (p=<0.001). In patients with hypertrophic cardiomyopathy, decreased 123I-BMIPP uptake compared to delayed 201Tl was observed in 65% of myocardial segments with reversible exercise 201Tl defects (p<0.001).
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