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November 1, 1993Nuclear Medicine Communications

Discrepancies between myocardial perfusion and free fatty acid metabolism in patients with hypertrophic cardiomyopathy

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Key result

BMIPP SPECT shows reduced uptake vs 201Tl in 40% of HCM segments, correlating with LVEF.

  • r = 0.748
  • P<0.01
  • n=17

Why the study?

Discrepancies between myocardial perfusion and fatty acid metabolism in hypertrophic cardiomyopathy were not well characterized, and the utility of BMIPP as a tracer for left ventricular function assessment was unclear.

Does 123I-BMIPP SPECT imaging reveal discrepancies in fatty acid metabolism compared to 201Tl perfusion and correlate with left ventricular function in patients with hypertrophic cardiomyopathy?

Comparison

201Tl vs 123I-beta-methylpentadecanoic acid (BMIPP) myocardial uptake

Design

Cross-sectional myocardial SPECT imaging study

Authors

TST. SHIMONAGATANational Cerebral and Cardiovascular CenterTNT NishimuraKyoto UniversityTUT Uehara

Discussion

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Implication

May support BMIPP SPECT for metabolic assessment in HCM; leaves open clinical adoption pending prospective validation.

Study Design

Type

Cross-Sectional (n=17)

Structured PICO

Does 123I-BMIPP SPECT imaging reveal discrepancies in fatty acid metabolism compared to 201Tl perfusion and correlate with left ventricular function in patients with hypertrophic cardiomyopathy?

P
Population
17 subjects, including 5 normal controls and 12 patients with asymmetric septal hypertrophy, evaluated with myocardial SPECT.
E
Exposure
Myocardial single photon emission computed tomography (SPECT) with 201Tl and 123I-beta-methylpentadecanoic acid (BMIPP).
C
Comparator
Normal subjects (for tracer distribution comparison) and intra-subject comparison of 201Tl vs BMIPP uptake.
O
Outcome
Tracer uptake in the left ventricular myocardium scored using a four-point grading system, and correlation with left ventricular ejection fraction.surrogate

Main Result

Effect estimate: r = 0.748

p-value: p=< 0.01

BMIPP SPECT imaging demonstrates impaired fatty acid metabolism in hypertrophic cardiomyopathy and serves as a useful tracer for assessing left ventricular function.

Cite This Study

SHIMONAGATA et al. (1993) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=17). 123I-BMIPP SPECT vs. 201Tl SPECT was evaluated on Correlation between BMIPP perfusion score and left ventricular ejection fraction (r = 0.748, p=< 0.01). BMIPP SPECT showed reduced uptake compared to 201Tl in 40% of myocardial segments in HCM patients and significantly correlated with left ventricular ejection fraction (r=0.748; P<0.01).

synapsesocial.com/papers/6aaa59df1d9c118b835e4b97https://doi.org/10.1097/00006231-199311000-00012

Topics

Hypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial metabolism of 123I-BMIPP in patients with hypertrophic cardiomyopathy1995 · 18 citations
  2. 2Assessment of myocardial fatty acid metabolic abnormalities in patients with idiopathic dilated cardiomyopathy using <sup>123</sup>I BMIPP SPECT: correlation with clinicopathological findings and clinical course1999 · 78 citations
  3. 3Myocardial Metabolic Abnormalities in Hypertrophic Cardiomyopathy Assessed by Iodine-123-Labeled Beta-Methyl-Branched Fatty Acid Myocardial Scintigraphy and its Relation to Exercise-Induced lschemia1998 · 33 citations
  4. 4Clinical Value of Iodine-123 Beta-Methyliodophenyl Pentadecanoic Acid (BMIPP) Myocardial Single Photon Emission Computed Tomography for Predicting Cardiac Death Among Patients With Chronic Heart Failure2003 · 9 citations
  5. 5Myocardial impairment detected by late gadolinium enhancement in hypertrophic cardiomyopathy: comparison with 99mTc-MIBI/tetrofosmin and 123I-BMIPP SPECT.2013 · 7 citations