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August 3, 2017Journal of Nuclear MedicineOpen Access

Prognostic Value of 123I-BMIPP SPECT in Patients with Nonischemic Heart Failure with Preserved Ejection Fraction

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Why the study?

Does a high 123I-BMIPP SPECT defect score predict major adverse cardiac events in patients with nonischemic heart failure with preserved ejection fraction?

Population

133 patients admitted to the hospital for acute heart failure with normal coronary arteries by invasive…

Comparison

High 123I-BMIPP SPECT defect score (≥4) vs Low 123I-BMIPP SPECT defect score (<4)

Design

Cohort

Follow-up

mean 2.5 y

Authors

HHHidenobu HashimotoRNRine NakanishiSMSunao Mizumura

Discussion

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Overview

BMIPP defect score may aid risk stratification in nonischemic HFpEF; leaves open incremental value over standard models.

Structured PICO

Does a high 123I-BMIPP SPECT defect score predict major adverse cardiac events in patients with nonischemic heart failure with preserved ejection fraction?

P
Population
133 patients admitted to the hospital for acute heart failure with normal coronary arteries by invasive coronary angiography and preserved left ventricular ejection fraction (≥50%) by echocardiography, mean age 73 ± 13 years.
I
Intervention
High 123I-BMIPP SPECT defect score (≥4)
C
Comparator
Low 123I-BMIPP SPECT defect score (<4)
O
Outcome
Major adverse cardiac events (composite of cardiac death, cardiovascular events, and hospitalization for heart failure) over a mean follow-up of 2.5 yearscomposite

A high 123I-BMIPP SPECT defect score is a strong independent predictor of major adverse cardiac events in patients with nonischemic heart failure with preserved ejection fraction.

Cite This Study

Hashimoto et al. (2017) studied this question.

synapsesocial.com/papers/6a709ee92163a0a01bc4d758https://doi.org/10.2967/jnumed.117.195743
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