Why the study?
Does tissue-specific regulation of ACE2 by diet and sex hormones contribute to sex differences in obesity-hypertension in mice?
Population
C57BL/6 mice (male and female, including ACE2 deficient and ovariectomized models)
Comparison
High-fat diet feeding, with or without losartan… vs Sex differences, standard diet, or vehicle…
Design
Preclinical
Authors
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Suggests sex-specific ACE2 pathways in obesity-hypertension; leaves open human translation and therapeutic targeting.
Does tissue-specific regulation of ACE2 by diet and sex hormones contribute to sex differences in obesity-hypertension in mice?
Tissue-specific regulation of ACE2 by diet and estrogen contributes to sex differences in the development of obesity-induced hypertension in mice.
Gupte et al. (2012) studied this question.
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