Why the study?
Do hypercalcemia and/or high PTH independently cause carotid atherosclerosis in patients with primary hyperparathyroidism, or is it driven by classic cardiovascular risk factors?
Population
41 subjects, including 26 consecutive patients with primary hyperparathyroidism [10 without risk factors, 16…
Comparison
Primary hyperparathyroidism with or without… vs Normocalcemic healthy subjects and PHPT patients…
Design
Cross-sectional
Authors
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Classic CV risk factors may drive carotid atherosclerosis in PHPT; leaves open independent PTH effects.
Do hypercalcemia and/or high PTH independently cause carotid atherosclerosis in patients with primary hyperparathyroidism, or is it driven by classic cardiovascular risk factors?
Increased cardiovascular risk in primary hyperparathyroidism appears to be driven by the combined presence of classic cardiovascular risk factors rather than hypercalcemia or PTH elevation alone.
Fallo et al. (2003) studied this question.
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