Key result
Primary hyperparathyroidism in normotensive patients was associated with significantly greater carotid intimal-medial thickness (P<0.001) and more atherosclerotic plaques (40% vs 10%, P=0.091).
Why the study?
Does primary hyperparathyroidism affect blood pressure profile, left ventricular mass, or carotid intima-media thickness in normotensive symptomless patients?
Population
20 normotensive symptomless patients with primary hyperparathyroidism, median age 51.5 years, and 20…
Comparison
Primary hyperparathyroidism (PHPT) vs Controls matched for age, gender, and body mass…
Design
Case-control
Authors
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Hypothesis-generating for subclinical atherosclerosis in normotensive primary hyperparathyroidism; prospective studies needed before clinical adoption.
Case-Control (n=40)
Does primary hyperparathyroidism affect blood pressure profile, left ventricular mass, or carotid intima-media thickness in normotensive symptomless patients?
p-value: p=<0.001
Normotensive symptomless patients with primary hyperparathyroidism exhibit early atherosclerotic changes as evidenced by increased carotid intima-media thickness, despite normal blood pressure and left ventricular mass.
Nuzzo et al. (2002) conducted a case-control in Primary hyperparathyroidism (n=40). Primary hyperparathyroidism vs. Matched controls was evaluated on carotid intimal-medial thickness (IMT) and atherosclerotic plaques (p=<0.001). Primary hyperparathyroidism in normotensive patients was associated with significantly greater carotid intimal-medial thickness (P<0.001) and more atherosclerotic plaques (40% vs 10%, P=0.091).
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