Why the study?
Does postural challenge reveal differences in heart rate variability in male patients with Alcohol-Dependence Syndrome compared to healthy controls?
Does postural challenge reveal differences in heart rate variability in male patients with Alcohol-Dependence Syndrome compared to healthy controls?
Patients with Alcohol-Dependence Syndrome exhibit attenuated cardiac vagal and sympathetic responses to standing, suggesting early autonomic dysfunction.
Attenuated HRV responses to standing may indicate early autonomic dysfunction in ADS; leaves open clinical relevance and need for prospective validation.
BACKGROUND: Cardiac autonomic involvement in Alcohol-Dependence Syndrome (ADS) patients has been demonstrated using conventional autonomic tests. Resting heart rate variability (HRV) without normalization has also been reported. AIMS: To evaluate cardiac autonomic changes with postural challenge using HRV in ADS and controls while controlling for confounding factors. SETTINGS AND DESIGN: Cross-sectional study involving 27 male subjects with ADS and age-matched healthy controls. MATERIALS AND METHODS: Clinical assessments included Schedules for Clinical Assessment in Neuropsychiatry and Severity of Alcohol Dependence Questionnaire. Spectral measures of HRV while lying and with active standing were assessed. RESULTS: There was an attenuated response in delta high-frequency (P=0.06) and delta low-frequency (P=0.04) power to standing in ADS subjects compared with controls. CONCLUSION: Patients with ADS appear to have attenuated cardiac vagal and sympathetic responses to standing. HRV with postural challenge may help earlier recognition of autonomic dysfunction in ADS.
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Srinivasan et al. (2012) studied this question.
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