Key result
Detoxified alcohol-dependent males exhibited significantly lower sleep heart-rate variability compared to healthy controls, including reduced SDNN (76.6 vs 96.8 ms) and total power.
Why the study?
Does alcohol dependence reduce sleep heart-rate variability in detoxified males compared to healthy controls?
Population
38 males, comprising 20 alcohol-dependent inpatients on the 5th day after detoxification and 18 age- and…
Comparison
Alcohol dependence (exposure) vs Age- and gender-matched healthy controls
Design
Case-control
Authors
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May signal autonomic neuropathy in detoxified alcohol dependence; leaves open predictive value for relapse or CV outcomes.
Case-Control (n=38)
No
Does alcohol dependence reduce sleep heart-rate variability in detoxified males compared to healthy controls?
Absolute Event Rate: 76.6% vs 96.8%
p-value: p=0.007
Detoxified alcohol-dependent males exhibit significantly decreased sleep heart-rate variability compared to healthy controls, suggesting underlying autonomic neuropathy.
Muralidharan et al. (2013) conducted a case-control in Alcohol dependence syndrome (n=38). Alcohol dependence vs. Healthy controls was evaluated on Standard deviation of all NN intervals (SDNN) during sleep (p=0.007). Detoxified alcohol-dependent males exhibited significantly lower sleep heart-rate variability compared to healthy controls, including reduced SDNN (76.6 vs 96.8 ms) and total power.
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