Why the study?
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, creating a need to explore the expanding applications of mock circulation loops beyond traditional roles in testing ventricular assist devices and heart failure management.
Mock circulation loops serve as critical research platforms for simulating cardiovascular hemodynamics and advancing experimental research.
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MCLs expand cardiovascular hemodynamics research platforms; leaves open clinical translation and device testing applications.
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, underscoring the need for continuous innovation in diagnostics and treatment. Mock circulation loops (MCLs) systems have recently emerged as new research platforms capable of replicating the hemodynamics of the human cardiovascular system. This review explores the expanding applications of MCLs to cardiovascular diseases beyond their traditional role in testing ventricular assist devices and heart failure management. We focus on their versatility in simulating various cardiovascular conditions, particularly arterial diseases such as atherosclerosis, stenosis, and aneurysms. This review traces the evolution of MCLs and their integration with computational simulations and real-time data acquisition systems. MCLs provide detailed insights into hemodynamic responses under diverse conditions, enhancing the precision and safety of cardiovascular interventions. This comprehensive review emphasizes the critical role of MCLs in advancing cardiovascular research, refining clinical interventions, and improving patient outcomes.
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Hong et al. (2025) studied this question.
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