Why the study?
Cardiovascular risk factor impacts differ by bariatric procedure, prompting evaluation of the effects of RYGB and SG on HDL protein and lipid cargo and their associations with changes in CEC.
Does bariatric surgery alter HDL lipid and protein cargo and cholesterol efflux capacity in nondiabetic, premenopausal Hispanic women with severe obesity?
Population
Nondiabetic, premenopausal Hispanic women with severe obesity not using lipid medications undergoing RYGB (n=31) or SG (n=36)
Comparison
RYGB vs SG
Design
Prospective cohort study
Follow-up
12 months
Authors
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SG may offer greater HDL functional gains than RYGB; leaves open differential CV outcome impact by procedure.
Does bariatric surgery alter HDL lipid and protein cargo and cholesterol efflux capacity in nondiabetic, premenopausal Hispanic women with severe obesity?
Bariatric surgery induces significant changes in HDL lipid and protein composition that mediate improvements in cholesterol efflux capacity, potentially contributing to reduced cardiovascular risk.
Zahid et al. (2025) studied this question.
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