Why the study?
Does a high-fat diet-induced type 2 diabetes model induce endothelial dysfunction and increase neointimal formation in C57BL/6J mice?
Population
C57BL/6J mice model of diet-induced obesity and type 2 diabetes
Comparison
High-fat diet for 9 weeks and femoral artery… vs Short-term high-fat diet feeding
Design
Preclinical
Follow-up
9 weeks
Authors
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Diabetic endothelial dysfunction via eNOS dimer disruption does not increase neointimal lesions in mice; leaves open relevance to human vascular injury responses.
Does a high-fat diet-induced type 2 diabetes model induce endothelial dysfunction and increase neointimal formation in C57BL/6J mice?
In a mouse model of diet-induced obesity and type 2 diabetes, endothelial dysfunction is driven by disrupted eNOS dimer formation rather than impaired insulin signaling, but this does not translate to increased neointimal formation without additional factors like hyperlipidemia.
Molnár et al. (2005) studied this question.
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