Why the study?
Does daily use of selective serotonin-reuptake inhibitors increase the risk of fragility fractures in community-dwelling subjects aged over 50 years?
Does daily use of selective serotonin-reuptake inhibitors increase the risk of fragility fractures in community-dwelling subjects aged over 50 years?
Daily use of selective serotonin-reuptake inhibitors in older adults is associated with a twofold increased risk of fragility fractures and falls, along with lower bone mineral density.
May warrant monitoring falls in older SSRI users; leaves open causality without RCTs.
Evaluation of: Richards JB, Papaioannou A, Adachi JD et al.: Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch. Intern. Med. 167, 188–194 (2007) [1]. The results of a cohort study of 5008 community-dwelling subjects aged over 50 years was presented. Among these, 137 were daily users of selective serotonin-reuptake inhibitors. The study reported an increased risk of fragility fractures (fractures occurring after minimal trauma; hazard ratio: 2.1; 95% confidence interval: 1.3–3.4) and an increased risk of falls (hazard ratio: 2.2; 95% confidence interval: 1.4–3.5) among daily users of selective serotonin-reuptake inhibitors. Bone mineral density was lower in the hip in daily selective serotonin-reuptake inhibitors users and there was a trend towards lower bone mineral density in the spine. A dose–response relationship was present.
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Peter Vestergaard (2007) studied this question.